Express. Lyse. Release.

PandaPure®, the next-generation bioprocessing for protein purification.
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Chromatography-free

Purify proteins with synthetic organelles - no columns or beads required.

Protease-free

Utilize a self-cleaving mechanism, mimicking signal tag removal in organelles.

Scale in parallel

Cell-based programming enables high throughput and scalable productions.

Get to know PandaPure

The next-generation bioprocessing solution for protein expression and purification.
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Easier to Learn. Easy to Love.

Minimal steps, basic lab equipment.

PandaPure system can be scaled down to small volumes, and potentially up to very large volume of fermentation.
Mechanism
Purify with organelles in vivo.

Learnt from nature. Remade for our need.

PandaPure system can be scaled down to small volumes, and potentially up to very large volume of fermentation.
Purification
The least effort. A better result.

Cells do the heavy lifting autonomously, with just a little help from you.

PandaPure system can be scaled down to small volumes, and potentially up to very large volume of fermentation.
Expression
Express proteins, a better way.

Mimic the function of secretory granules.

PandaPure system can be scaled down to small volumes, and potentially up to very large volume of fermentation.
High throughput
More proteins. Less time.

Get faster, high-volume results with multi-well parallel processing and automation.

PandaPure system can be scaled down to small volumes, and potentially up to very large volume of fermentation.
Scalability
Flexible scaling for R&D needs.

Adaptable from μl screening to liter-scale applications.

PandaPure system can be scaled down to small volumes, and potentially up to very large volume of fermentation.
Sustainability
Greener and safer

Reduce uses of seaweed-based resins and chemicals, with process integration.

PandaPure system can be scaled down to small volumes, and potentially up to very large volume of fermentation.
Cost-effectiveness
More you use, more you save.

Cuts total cost of workflow by up to 10x.

PandaPure system can be scaled down to small volumes, and potentially up to very large volume of fermentation.
How it works

Now, protein purification is easier than ever.

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Build

Cloning your genes into PandaPure Expression Vector, and prepare the PandaPure Construct.

Express

Induce expression of protein and organelle-mediated sorting by IPTG and aTc, respectively.

Lyse

Open the cell structures by disrupting cell membrane and/or cell walls, to isolate organelles enriched with target proteins.

Release and recover target proteins

React organelles with PandaPure® Protein Reagent, and recover tag-less proteins in a simple centrifugation.
The science behind PandaPure

Take a closer look

cells are isolating your proteins.

Synthetic organelles,
the power behind isolation.
PandaPure® Protein Constructs include an organelle plasmid that encodes the formation of synthetic organelles. These engineered organelles are designed to display specific receptors, selectively recruiting proteins of interest that are tagged with the correct signal.
Efficient protein recovery,
with tag self-removal.
The PandaPure® Protein Reagent triggers self-cleavage of signal tags and releases tag-free proteins in a single, mild reaction. This innovative process ensures high purity without harsh conditions.
Learn more at our preprint.
Express

A boarder range of proteins.

Now, proteins are expressed in a more "eukaryotic" way, i.e. folded, matured, and stored in synthetic organelles, a distinct microenvironment. This innovation significantly broadens the range of expressible proteins and often results in higher yields.
Challenge PandaPure
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sfGFP
The superfolder version of green fluorescent protein.
PandaPure successfully produces GFP at high yield and purity.
Scope of applications
Proinsulin
Precursor of insulin, the first biologics. Difficult to express due to disulfide bonds.
PandaPure successfully produces GFP at high yield and purity.
Scope of applications
DpnI
Widely-used restriction enzyme of Gm6A^TC sites. Lethal to Dam+Dcm+ hosts!
PandaPure successfully produces GFP at high yield and purity.
Scope of applications
PandaPure reduces protein purification to just a few liquid-handling. Now, anyone with basic molecular biology training can now perform purification easily!
PandaPure cuts benchwork to under 30 minutes. Now you can save half a day from the wet lab on something else!
PandaPure combines all functions in one system, at a cost comparable to basic His-tag purification. Traditional methods need separate reagents, driving up expenses.
Offerings

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Join scientists transforming their research with PandaPure. Simplify your protein purification with synthetic organelles today.
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PandaPure®️ Kits

Applications from lab-scale to high-throughput productions.

Construct Service

Get ready-to-use DNA constructs at a competitive price from $0.1 per bp.

PandaPure®️ Plasmids

Plasmids for synthetic organelles, expression vectors, and for controls.

MTA & licensing

Contact us for joint research, industrial licensing, or other custom needs.
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